ECGene: A Literature-Based Knowledgebase of Endometrial Cancer Genes.

ABSTRACT: Endometrial cancer (EC) ranks as the sixth common cancer for women worldwide. To better distinguish cancer subtypes and identify effective early diagnostic biomarkers, we need improved understanding of the biological mechanisms associated with EC dysregulated genes. Although there is a wealth of clinical and molecular information relevant to EC in the literature, there has been no systematic summary of EC-implicated genes. In this study, we developed a literature-based database ECGene (Endometrial Cancer Gene database) with comprehensive annotations. ECGene features manual curation of 414 genes from thousands of publications, results from eight EC gene expression datasets, precomputation of coexpressed long noncoding RNAs, and an EC-implicated gene interactome. In the current release, we g

SUBMITTER: Zhao M 

PROVIDER: S-EPMC5066700 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature