Differential expression of two activating transcription factor 5 isoforms in papillary thyroid carcinoma.

ABSTRACT:

Background

Activating transcription factor 5 (ATF5) is a member of the activating transcription/cAMP response element-binding protein family of basic leucine zipper proteins that plays an important role in cell survival, differentiation, proliferation, and apoptosis. The ATF5 gene generates two transcripts: ATF5 isoform 1 and ATF5 isoform 2. A number of studies indicate that ATF5 could be an attractive target for therapeutic intervention in several tumor types; however, so far, the role of ATF5 has not been investigated in papillary thyroid carcinoma (PTC).

Methods

Quantitative real-time reverse transcription polymerase chain reaction and immuno-histochemical staining were used to study ATF5 mRNA and protein expression in PTC.

SUBMITTER: Vicari L 

PROVIDER: S-EPMC5067000 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature