Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient.

ABSTRACT:

Introduction

In recent years, treatment of intractable epilepsy has become more challenging, due to an increase in resistance to antiepileptic drugs, as well as diminished success following resection surgery. Here, we present the case of a 19-year old epileptic patient who received vagus nerve stimulation (VNS) following unsuccessful left parietal-occipital lesion-resection surgery, with results indicating an approximate 50% reduction in seizure frequency and a much longer seizure-free interictal phase.

Materials and methods

Using resting-state functional magnetic resonance imaging, we measured the changes in resting-state brain networks between pre-VNS treatment and 6 months post-VNS, from the perspective of regional and global variations, using regional homogeneity and lar

SUBMITTER: Wang K 

PROVIDER: S-EPMC5067064 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature