A negative relationship between ventral striatal loss anticipation response and impulsivity in borderline personality disorder.

ABSTRACT: Patients with borderline personality disorder (BPD) frequently exhibit impulsive behavior, and self-reported impulsivity is typically higher in BPD patients when compared to healthy controls. Previous functional neuroimaging studies have suggested a link between impulsivity, the ventral striatal response to reward anticipation, and prediction errors. Here we investigated the striatal neural response to monetary gain and loss anticipation and their relationship with impulsivity in 21 female BPD patients and 23 age-matched female healthy controls using functional magnetic resonance imaging (fMRI). Participants performed a delayed monetary incentive task in which three categories of objects predicted a potential gain, loss, or neutral outcome. Impulsivity was assessed using the Barratt Impuls

SUBMITTER: Herbort MC 

PROVIDER: S-EPMC5067102 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature