Phage display for identification of serum biomarkers of traumatic brain injury.

ABSTRACT:

Background

The extent and severity of traumatic brain injuries (TBIs) can be difficult to determine with current diagnostic methods. To address this, there has been increased interest in developing biomarkers to assist in the diagnosis, determination of injury severity, evaluation of recovery and therapeutic efficacy, and prediction of outcomes. Several promising serum TBI biomarkers have been identified using hypothesis-driven approaches, largely examining proteins that are abundant in neurons and non-neural cells in the CNS.

New method

An unbiased approach, phage display, was used to identify serum TBI biomarkers. In this proof-of-concept study, mice received a TBI using the controlled cortical impact model of TBI (1mm injury depth, 3.5m/s velocity) and phage display was u

SUBMITTER: Ghoshal S 

PROVIDER: S-EPMC5067197 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature