MyT1 Counteracts the Neural Progenitor Program to Promote Vertebrate Neurogenesis.

ABSTRACT: The generation of neurons from neural stem cells requires large-scale changes in gene expression that are controlled to a large extent by proneural transcription factors, such as Ascl1. While recent studies have characterized the differentiation genes activated by proneural factors, less is known on the mechanisms that suppress progenitor cell identity. Here, we show that Ascl1 induces the transcription factor MyT1 while promoting neuronal differentiation. We combined functional studies of MyT1 during neurogenesis with the characterization of its transcriptional program. MyT1 binding is associated with repression of gene transcription in neural progenitor cells. It promotes neuronal differentiation by counteracting the inhibitory activity of Notch signaling at multiple levels, targeting th

SUBMITTER: Vasconcelos FF 

PROVIDER: S-EPMC5067283 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature