Genetic and pathogenic characterisation of 11 avian reovirus isolates from northern China suggests continued evolution of virulence.

ABSTRACT: Avian reovirus (ARV) infections characterised by severe arthritis, tenosynovitis, pericarditis, and depressed growth have become increasingly frequent in recent years. In this study, we isolated and identified 11 ARV field strains from chickens with viral arthritis and reduced growth in northern China. Comparative analysis of the σC nucleotide and amino acid sequences demonstrated that all isolates, except LN05 and JS01, were closely related to ARV S1133 and clustered in the first genetic lineage. LN05 and JS01 strains were clustered in the third lineage with the ARV 138 strain. Using S1133 as a reference, five isolates were selected to infect specific-pathogen-free chickens, and we found that the recent isolated Chinese ARV strains had higher replication ability in vivo and caused enhance

SUBMITTER: Zhong L 

PROVIDER: S-EPMC5067505 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature