Longitudinal Measurements of Cerebrospinal Fluid Biomarkers in Parkinson's Disease.

ABSTRACT:

Objective

The purpose of this study was to investigate whether cerebrospinal fluid (CSF) levels of tau, phosphorylated tau, β-amyloid42 , α-synuclein, neurofilament light, and YKL-40 change over time and if changes correlate with motor progression and/or cognitive decline in patients with PD and controls.

Methods

We included 63 patients with PD (nondemented) and 21 neurologically healthy controls from the prospective and longitudinal Swedish BioFINDER study, all of whom had clinical assessments and lumbar punctures at baseline and after 2 years.

Results

CSF tau levels correlated strongly with α-synuclein. The levels of CSF α-synuclein, tau, phosphorylated tau, neurofilament light, and YKL-40, but not β-amyloid42 , increased in CSF over 2 years in PD. No changes were s

SUBMITTER: Hall S 

PROVIDER: S-EPMC5067556 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature