Comparative Effectiveness of Prestroke Aspirin on Stroke Severity and Outcome.

ABSTRACT:

Objective

The effect of prestroke aspirin use on initial severity, hemorrhagic transformation, and functional outcome of ischemic stroke is uncertain.

Methods

Using a multicenter stroke registry database, patients with acute ischemic stroke of three subtypes (large artery atherosclerosis [LAA], small vessel occlusion [SVO], or cardioembolism [CE]) were identified. NIH stroke scale (NIHSS) and hemorrhagic transformation at presentation and discharge modified Rankin Scale (mRS) were compared between prestroke aspirin users and nonusers.

Results

Among the 10,433 patients, 1,914 (18.3%) reported prestroke aspirin use. On crude analysis, initial NIHSS scores of aspirin users were higher than nonusers (mean difference: 0.35; 95% confidence interval [CI]: 0.04-0.66). However

SUBMITTER: Park JM 

PROVIDER: S-EPMC5067647 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature