Salmonella Extracellular Matrix Components Influence Biofilm Formation and Gallbladder Colonization.

ABSTRACT: Salmonella enterica serovar Typhi, the causative agent of typhoid fever in humans, forms biofilms encapsulated by an extracellular matrix (ECM). Biofilms facilitate colonization and persistent infection in gallbladders of humans and mouse models of chronic carriage. Individual roles of matrix components have not been completely elucidated in vitro or in vivo To examine individual functions, strains of Salmonella enterica serovar Typhimurium, the murine model of S Typhi, in which various ECM genes were deleted or added, were created to examine biofilm formation, colonization, and persistence in the gallbladder. Studies show that curli contributes most significantly to biofilm formation. Expression of Vi antigen decreased biofilm formation in vitro and virulence and bacterial survival in viv

SUBMITTER: Adcox HE 

PROVIDER: S-EPMC5067756 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature