Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis.

ABSTRACT:

Rationale

Despite shared environmental exposures, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease are usually studied in isolation, and the presence of shared molecular mechanisms is unknown.

Objectives

We applied an integrative genomic approach to identify convergent transcriptomic pathways in emphysema and IPF.

Methods

We defined the transcriptional repertoire of chronic obstructive pulmonary disease, IPF, or normal histology lungs using RNA-seq (n = 87).

Measurements and main results

Genes increased in both emphysema and IPF relative to control were enriched for the p53/hypoxia pathway, a finding confirmed in an independent cohort using both gene expression arrays and the nCounter Analysis System (n = 193). Immunohistochemistry

SUBMITTER: Kusko RL 

PROVIDER: S-EPMC5067817 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature