Abnormal Glucose Tolerance in Infants and Young Children with Cystic Fibrosis.

ABSTRACT:

Rationale

In cystic fibrosis, abnormal glucose tolerance is associated with decreased lung function and worsened outcomes. Translational evidence indicates that abnormal glucose tolerance may begin in early life.

Objectives

To determine whether very young children with cystic fibrosis have increased abnormal glucose tolerance prevalence compared with control subjects. The secondary objective was to compare area under the curve for glucose and insulin in children with cystic fibrosis with control subjects.

Methods

This is a prospective multicenter study in children ages 3 months to 5 years with and without cystic fibrosis.

Measurements and main results

Oral glucose tolerance testing with glucose, insulin, and C-peptide was sampled at 0, 10, 30, 60, 90, and 120 m

SUBMITTER: Yi Y 

PROVIDER: S-EPMC5067820 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature