Increased Steady-State Memory B Cell Subsets Among High-Risk Participants in an HIV Vaccine Trial.

ABSTRACT: The success of an HIV vaccine will require induction of a protective immune response in the most at-risk populations. The increased incidence of HIV infection in high-risk populations is assumed to be primarily the result of more frequent exposure to the virus or a greater inoculum of the virus; however, underlying variations in immune homeostasis may also contribute to HIV susceptibility and potentially impact vaccine responses and those required for protection. As an effective humoral immune response is likely to be a critical component of a protective HIV vaccine, we evaluated the steady-state phenotypic profile of peripheral blood B cells by flow cytometry from participants in the HIV Vaccine Trials Network (HVTN) 203 Phase 2a HIV vaccine trial considered to be at higher risk and lower

SUBMITTER: Keefer MC 

PROVIDER: S-EPMC5067846 | biostudies-literature | 2016 Oct/Nov

REPOSITORIES: biostudies-literature