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The Polarization of M2b Monocytes in Cultures of Burn Patient Peripheral CD14⁺ Cells Treated with a Selected Human CCL1 Antisense Oligodeoxynucleotide.

ABSTRACT: M2b macrophages (Mφ) play a major role in the increased susceptibility of subacutely burned patients, to sepsis stemming from enterococcal translocation. Certain opportunistic infections in severely burned mice have been controlled by murine CCL1 antisense oligodeoxynucleotide (ODN), a specific polarizer of mouse M2bMφ. In the present study, we have screened CCL1 antisense ODN, which is active against human M2bMφ. Among the 20 CCL1 antisense ODNs synthesized in our laboratory, HCA-11 was shown to be the most active polarizer for human CCL1⁺CD163⁺CD14⁺ cells. Burn patient CCL1⁺CD163⁺CD14⁺ cells (3 × 10⁵ cells/mL) switched to quiescent CCL1^-CD163^-CD14⁺ cells within 48 h in cultures s

SUBMITTER: Ito I

PROVIDER: S-EPMC5067856 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Dataset Information

The Polarization of M2b Monocytes in Cultures of Burn Patient Peripheral CD14⁺ Cells Treated with a Selected Human CCL1 Antisense Oligodeoxynucleotide.

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Dataset Information

The Polarization of M2b Monocytes in Cultures of Burn Patient Peripheral CD14+ Cells Treated with a Selected Human CCL1 Antisense Oligodeoxynucleotide.

OmicsDI is part of the ELIXIR infrastructure

Tweets

The Polarization of M2b Monocytes in Cultures of Burn Patient Peripheral CD14⁺ Cells Treated with a Selected Human CCL1 Antisense Oligodeoxynucleotide.