The Alternative Splicing Gallery (ASG): bridging the gap between genome and transcriptome.

ABSTRACT: Alternative splicing essentially increases the diversity of the transcriptome and has important implications for physiology, development and the genesis of diseases. Conventionally, alternative splicing is investigated in a case-by-case fashion, but this becomes cumbersome and error prone if genes show a huge abundance of different splice variants. We use a different approach and integrate all transcripts derived from a gene into a single splicing graph. Each transcript corresponds to a path in the graph, and alternative splicing is displayed by bifurcations. This representation preserves the relationships between different splicing variants and allows us to investigate systematically all possible putative transcripts. We built a database of splicing graphs for human genes, using transcrip

SUBMITTER: Leipzig J 

PROVIDER: S-EPMC506815 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature