Outcomes of Pancreatic Islet Allotransplantation Using the Edmonton Protocol at the University of Chicago.

ABSTRACT:

Objective

The aim of this study was to assess short-term and long-term results of the pancreatic islet transplantation using the Edmonton protocol at the University of Chicago.

Materials and methods

Nine patients underwent pancreatic islet cell transplantation using the Edmonton Protocol; they were followed up for 10 years after initial islet transplant with up to 3 separate islet infusions. They were given induction treatment using an IL-2R antibody and their maintenance immunosuppression regimen consisted of sirolimus and tacrolimus.

Results

Nine patients received a total of 18 islet infusions. Five patients dropped out in the early phase of the study. Greater than 50% drop-out and noncompliance rate resulted from both poor islet function and recurrent side effects

SUBMITTER: Tekin Z 

PROVIDER: S-EPMC5068201 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature