Calorie restriction protects against experimental abdominal aortic aneurysms in mice.

ABSTRACT: Abdominal aortic aneurysm (AAA), characterized by a localized dilation of the abdominal aorta, is a life-threatening vascular pathology. Because of the current lack of effective treatment for AAA rupture, prevention is of prime importance for AAA management. Calorie restriction (CR) is a nonpharmacological intervention that delays the aging process and provides various health benefits. However, whether CR prevents AAA formation remains untested. In this study, we subjected Apoe^-/- mice to 12 wk of CR and then examined the incidence of angiotensin II (AngII)-induced AAA formation. We found that CR markedly reduced the incidence of AAA formation and attenuated aortic elastin degradation in Apoe^-/- mice. The expression and activity of Sirtuin 1 (SIRT1), a key metabolism/

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5068228 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature