CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.

ABSTRACT: It is well established that Ly6C^hi monocytes develop from common monocyte progenitors (cMoPs) and reside in the bone marrow (BM) until they are mobilized into the circulation. In our study, we found that BM Ly6C^hi monocytes are not a homogenous population, as current data would suggest. Using computational analysis approaches to interpret multidimensional datasets, we demonstrate that BM Ly6C^hi monocytes consist of two distinct subpopulations (CXCR4^hi and CXCR4^lo subpopulations) in both mice and humans. Transcriptome studies and in vivo assays revealed functional differences between the two subpopulations. Notably, the CXCR4^hi subset proliferates and is immobilized in the BM for the replenishment of functionally mature CXCR4

SUBMITTER: Chong SZ 

PROVIDER: S-EPMC5068243 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature