Optimal Cervical Cancer Screening in Women Vaccinated Against Human Papillomavirus.

ABSTRACT:

Background

Current US cervical cancer screening guidelines do not differentiate recommendations based on a woman's human papillomavirus (HPV) vaccination status. Changes to cervical cancer screening policies in HPV-vaccinated women should be evaluated.

Methods

We utilized an individual-based mathematical model of HPV and cervical cancer in US women to project the health benefits, costs, and harms associated with screening strategies in women vaccinated with the bivalent, quadrivalent, or nonavalent vaccine. Strategies varied by the primary screening test, including cytology, HPV, and combined cytology and HPV "cotesting"; age of screening initiation and/or switching to a new test; and interval between routine screens. Cost-effectiveness analysis was conducted from the societ

SUBMITTER: Kim JJ 

PROVIDER: S-EPMC5068562 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature