Associations between the schizophrenia susceptibility gene ZNF804A and clinical outcomes in psychosis.

ABSTRACT: We sought to test the hypothesis that the rs1344706 A allele will be associated with worse clinical outcome in first-episode psychosis. A data linkage was set up between a large systematic study of first-episode psychosis and an electronic health-record case register at the South London and Maudsley NHS Foundation Trust--a large provider of secondary mental-health care. A sample of 291 patients, who presented with a first psychotic episode (ICD10 diagnoses F20-29 or F30-33) and in whom the rs1344706 genotype had been assayed, were followed to examine the duration of mental-health in-patient care during the 2 years following first service contact, as a primary outcome. Secondary outcome measures were whether or not an in-patient episode occurred and the number of in-patient episodes during

SUBMITTER: Wickramasinghe A 

PROVIDER: S-EPMC5068593 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature