Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset.

ABSTRACT: Recent research efforts have progressively shifted towards preventative psychiatry and prognostic identification of individuals before disease onset. We describe the development of a serum biomarker test for the identification of individuals at risk of developing schizophrenia based on multiplex immunoassay profiling analysis of 957 serum samples. First, we conducted a meta-analysis of five independent cohorts of 127 first-onset drug-naive schizophrenia patients and 204 controls. Using least absolute shrinkage and selection operator regression, we identified an optimal panel of 26 biomarkers that best discriminated patients and controls. Next, we successfully validated this biomarker panel using two independent validation cohorts of 93 patients and 88 controls, which yielded an area under

SUBMITTER: Chan MK 

PROVIDER: S-EPMC5068725 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature