Motivation and value influences in the relative balance of goal-directed and habitual behaviours in obsessive-compulsive disorder.

ABSTRACT: Our decisions are based on parallel and competing systems of goal-directed and habitual learning, systems which can be impaired in pathological behaviours. Here we focus on the influence of motivation and compare reward and loss outcomes in subjects with obsessive-compulsive disorder (OCD) on model-based goal-directed and model-free habitual behaviours using the two-step task. We further investigate the relationship with acquisition learning using a one-step probabilistic learning task. Forty-eight OCD subjects and 96 healthy volunteers were tested on a reward and 30 OCD subjects and 53 healthy volunteers on the loss version of the two-step task. Thirty-six OCD subjects and 72 healthy volunteers were also tested on a one-step reversal task. OCD subjects compared with healthy volunteers wer

SUBMITTER: Voon V 

PROVIDER: S-EPMC5068758 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature