Increased serum levels of sortilin are associated with depression and correlated with BDNF and VEGF.

ABSTRACT: Neurotrophic factors have been investigated in relation to depression. The aim of the present study was to widen this focus to sortilin, a receptor involved in neurotrophic signalling. The serum sortilin level was investigated in 152 individuals with depression and 216 control individuals, and eight genetic markers located within the SORT1 gene were successfully analysed for association with depression. Genotyping was performed using the Sequenom MassARRAY platform. All the individuals returned a questionnaire and participated in a semi-structured diagnostic interview. Sortilin levels were measured by immunoassay, and potential determinants of the serum sortilin level were assessed by generalized linear models. Serum levels of brain-derived neurotrophic factor (BDNF) and vascular endotheli

SUBMITTER: Buttenschon HN 

PROVIDER: S-EPMC5068760 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature