Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder.

ABSTRACT: Several studies have reported that adults with major depressive disorder have shorter telomere length and reduced hippocampal volumes. Moreover, studies of adult populations without major depressive disorder suggest a relationship between peripheral telomere length and hippocampal volume. However, the relationship of these findings in adolescents with major depressive disorder has yet to be explored. We examined whether adolescent major depressive disorder is associated with altered peripheral telomere length and hippocampal volume, and whether these measures relate to one another. In 54 unmedicated adolescents (13-18 years) with major depressive disorder and 63 well-matched healthy controls, telomere length was assessed from saliva using quantitative polymerase chain reaction methods, and

SUBMITTER: Henje Blom E 

PROVIDER: S-EPMC5068765 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature