Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus.

ABSTRACT: The selective serotonin reuptake inhibitor (SSRI) fluoxetine is widely prescribed for the treatment of symptoms related to a variety of psychiatric disorders. After chronic SSRI treatment, some symptoms remediate on the long term, but the underlying mechanisms are not yet well understood. Here we studied the long-term consequences (40 days after treatment) of chronic fluoxetine exposure on genome-wide gene expression. During the treatment period, we measured body weight; and 1 week after treatment, cessation behavior in an SSRI-sensitive anxiety test was assessed. Gene expression was assessed in hippocampal tissue of adult rats using transcriptome analysis and several differentially expressed genes were validated in independent samples. Gene ontology analysis showed that upregulated genes

SUBMITTER: Kroeze Y 

PROVIDER: S-EPMC5068807 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature