Abnormal context-reward associations in an immune-mediated neurodevelopmental mouse model with relevance to schizophrenia.

ABSTRACT: Impairments in central reward processing constitute an important aspect of the negative symptoms of schizophrenia. Despite its clinical relevance, the etiology of deficient reward processing in schizophrenia remains largely unknown. Here, we used an epidemiologically informed mouse model of schizophrenia to explore the effects of prenatal immune activation on reward-related functions. The model is based on maternal administration of the viral mimic PolyI:C and has been developed in relation to the epidemiological evidence demonstrating enhanced risk of schizophrenia and related disorders following prenatal maternal infection. We show that prenatal immune activation induces selective deficits in the expression (but not acquisition) of conditioned place preference for a natural reward (sucro

SUBMITTER: Labouesse MA 

PROVIDER: S-EPMC5068811 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature