A common molecular signature in ASD gene expression: following Root 66 to autism.

ABSTRACT: Several gene expression experiments on autism spectrum disorders have been conducted using both blood and brain tissue. Individually, these studies have advanced our understanding of the molecular systems involved in the molecular pathology of autism and have formed the bases of ongoing work to build autism biomarkers. In this study, we conducted an integrated systems biology analysis of 9 independent gene expression experiments covering 657 autism, 9 mental retardation and developmental delay and 566 control samples to determine if a common signature exists and to test whether regulatory patterns in the brain relevant to autism can also be detected in blood. We constructed a matrix of differentially expressed genes from these experiments and used a Jaccard coefficient to create a gene-bas

SUBMITTER: Diaz-Beltran L 

PROVIDER: S-EPMC5068868 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature