Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study.

ABSTRACT: We studied peripheral leukocyte telomere length (LTL) as a predictor of antidepressant response to PPAR-γ agonist in patients with unremitted depression. In addition we examined correlation between LTL and the insulin resistance (IR) status in these subjects. Forty-two medically stable men and women ages 23-71 with non-remitted depression participated in double-blind placebo-controlled add-on of Pioglitazone to treatment-as-usual. Oral glucose tolerance tests were administered at baseline and at 12 weeks. Diagnostic evaluation of psychiatric disorders was performed at baseline and mood severity was followed weekly throughout the duration of the trial. At baseline, no differences in LTL were detected by depression severity, duration or chronicity. LTL was also not significantly different be

SUBMITTER: Rasgon N 

PROVIDER: S-EPMC5068869 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature