Blood metabolite markers of neocortical amyloid-β burden: discovery and enrichment using candidate proteins.

ABSTRACT: We believe this is the first study to investigate associations between blood metabolites and neocortical amyloid burden (NAB) in the search for a blood-based biomarker for Alzheimer's disease (AD). Further, we present the first multi-modal analysis of blood markers in this field. We used blood plasma samples from 91 subjects enrolled in the University of California, San Francisco Alzheimer's Disease Research Centre. Non-targeted metabolomic analysis was used to look for associations with NAB using both single and multiple metabolic feature models. Five metabolic features identified subjects with high NAB, with 72% accuracy. We were able to putatively identify four metabolites from this panel and improve the model further by adding fibrinogen gamma chain protein measures (accuracy=79%). One

SUBMITTER: Voyle N 

PROVIDER: S-EPMC5068879 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature