Preservation Analysis of Macrophage Gene Coexpression Between Human and Mouse Identifies PARK2 as a Genetically Controlled Master Regulator of Oxidative Phosphorylation in Humans.

ABSTRACT: Macrophages are key players involved in numerous pathophysiological pathways and an in-depth characterization of their gene regulatory networks can help in better understanding how their dysfunction may impact on human diseases. We here conducted a cross-species network analysis of macrophage gene expression data between human and mouse to identify conserved networks across both species, and assessed whether such networks could reveal new disease-associated regulatory mechanisms. From a sample of 684 individuals processed for genome-wide macrophage gene expression profiling, we identified 27 groups of coexpressed genes (modules). Six modules were found preserved (P < 10^-4) in macrophages from 86 mice of the Hybrid Mouse Diversity Panel. One of these modules was significantly [fa

SUBMITTER: Codoni V 

PROVIDER: S-EPMC5068955 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature