Modeling the dynamics of neonatal CD8⁺ T-cell responses.

ABSTRACT: Neonates are particularly susceptible to a number of infections, and the neonatal CD8⁺ T-cell response demonstrates differences in both the phenotype and magnitude of responses to infection compared with adults. However, the underlying basis for these differences is unclear. We have used a mathematical modeling approach to analyze the dynamics of neonatal and adult CD8⁺ T-cell responses following in vitro stimulation and in vivo infection, which allows us to dissect key cell-intrinsic differences in expansion, differentiation and memory formation. We found that neonatal cells started dividing 8 h earlier and proliferated at a faster rate (0.077 vs 0.105 per day) than adult cells in vitro. In addition, neonatal cells also differentiated more rapidly, as measured by the

SUBMITTER: Reynaldi A 

PROVIDER: S-EPMC5069106 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature