Exposure Enriched Case-Control (EECC) Design for the Assessment of Gene-Environment Interaction.

ABSTRACT: Genetic susceptibility and environmental exposure both play an important role in the aetiology of many diseases. Case-control studies are often the first choice to explore the joint influence of genetic and environmental factors on the risk of developing a rare disease. In practice, however, such studies may have limited power, especially when susceptibility genes are rare and exposure distributions are highly skewed. We propose a variant of the classical case-control study, the exposure enriched case-control (EECC) design, where not only cases, but also high (or low) exposed individuals are oversampled, depending on the skewness of the exposure distribution. Of course, a traditional logistic regression model is no longer valid and results in biased parameter estimation. We show that addit

SUBMITTER: Huque MH 

PROVIDER: S-EPMC5069109 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature