Neural Correlates of Wakefulness, Sleep, and General Anesthesia: An Experimental Study in Rat.

ABSTRACT:

Background

Significant advances have been made in our understanding of subcortical processes related to anesthetic- and sleep-induced unconsciousness, but the associated changes in cortical connectivity and cortical neurochemistry have yet to be fully clarified.

Methods

Male Sprague-Dawley rats were instrumented for simultaneous measurement of cortical acetylcholine and electroencephalographic indices of corticocortical connectivity-coherence and symbolic transfer entropy-before, during, and after general anesthesia (propofol, n = 11; sevoflurane, n = 13). In another group of rats (n = 7), these electroencephalographic indices were analyzed during wakefulness, slow wave sleep (SWS), and rapid eye movement (REM) sleep.

Results

Compared to wakefulness, anesthetic-induce

SUBMITTER: Pal D 

PROVIDER: S-EPMC5069172 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature