Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator.

ABSTRACT:

Purpose

Several studies implicated a crosstalk between bone and fat in the pathogenesis of osteoporosis. Few studies indicated an association between adiponectin and omentin-1 on the bone remodeling process and bone mineral density, and suggested osteoprotegerin (OPG) as a mediator of this relationship. However, only limited evidence on this relationship is available in humans. Therefore, this study aimed to investigate the association between omentin-1, adiponectin and broadband ultrasound attenuation (BUA) in peri-/premenopausal and postmenopausal women, and to assess the role of OPG as a possible mediator.

Methods

Data from the German population-based EPIC-Potsdam cohort comprising 637 women were analyzed. Multivariable-adjusted ANCOVA including age, BMI, waist circumfere

SUBMITTER: Menzel J 

PROVIDER: S-EPMC5069301 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature