Resting-state connectivity predicts levodopa-induced dyskinesias in Parkinson's disease.

ABSTRACT:

Background

Levodopa-induced dyskinesias are a common side effect of dopaminergic therapy in PD, but their neural correlates remain poorly understood.

Objectives

This study examines whether dyskinesias are associated with abnormal dopaminergic modulation of resting-state cortico-striatal connectivity.

Methods

Twelve PD patients with peak-of-dose dyskinesias and 12 patients without dyskinesias were withdrawn from dopaminergic medication. All patients received a single dose of fast-acting soluble levodopa and then underwent resting-state functional magnetic resonance imaging before any dyskinesias emerged. Levodopa-induced modulation of cortico-striatal resting-state connectivity was assessed between the putamen and the following 3 cortical regions of interest: supplemen

SUBMITTER: Herz DM 

PROVIDER: S-EPMC5069605 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature