Identification of potential candidate genes for hypertensive nephropathy based on gene expression profile.

ABSTRACT:

Background

This study was aimed to explore the molecular mechanisms of hypertensive nephropathy (HTN).

Methods

Gene expression profile of GSE37460, which based on 27 healthy living donor samples (HTN group) and 15 hypertensive nephropathy samples (control group), were downloaded from Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) between two groups were identified. STRING database was used to reveal protein-protein interaction (PPI) network of DEGs, followed by the functional enrichment analysis of the PPI network. Additionally, miRNA-DEG regulatory network was constructed to reveal the validated miRNAs targeting the DEGs.

Results

In total, 51 up-regulated genes and 140 down-regulated genes were obtained. In the PPI network, cytochro

SUBMITTER: Chen Z 

PROVIDER: S-EPMC5069870 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature