The NADPH oxidase NOX2 as a novel biomarker for suicidality: evidence from human post mortem brain samples.

ABSTRACT: Recent evidence points towards a role of oxidative stress in suicidality. However, few studies were carried out on the sources of reactive oxygen species (ROS) in subjects with suicidal behaviour. We have previously demonstrated that the NADPH oxidase NOX2-derived oxidative stress has a major role in the development of neuropathological alterations observed in an animal model of psychosis. Here, we investigated the possible increase in NOX2 in post mortem brain samples of subjects who died by asphyctic suicide (AS) compared with controls (CTRL) and subjects who died by non-suicidal asphyxia (NSA). We found that NOX2 expression was significantly higher in the cortex of AS subjects than in the other two experimental groups. NOX2 immunostaining was mainly detected in GABAergic neurons, with a

SUBMITTER: Schiavone S 

PROVIDER: S-EPMC5070044 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature