Atypical visual and somatosensory adaptation in schizophrenia-spectrum disorders.

ABSTRACT: Neurophysiological investigations in patients with schizophrenia consistently show early sensory processing deficits in the visual system. Importantly, comparable sensory deficits have also been established in healthy first-degree biological relatives of patients with schizophrenia and in first-episode drug-naive patients. The clear implication is that these measures are endophenotypic, related to the underlying genetic liability for schizophrenia. However, there is significant overlap between patient response distributions and those of healthy individuals without affected first-degree relatives. Here we sought to develop more sensitive measures of sensory dysfunction in this population, with an eye to establishing endophenotypic markers with better predictive capabilities. We used a senso

SUBMITTER: Andrade GN 

PROVIDER: S-EPMC5070065 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature