Convert your favorite protein modeling program into a mutation predictor: "MODICT".

ABSTRACT:

Background

Predict whether a mutation is deleterious based on the custom 3D model of a protein.

Results

We have developed MODICT, a mutation prediction tool which is based on per residue RMSD (root mean square deviation) values of superimposed 3D protein models. Our mathematical algorithm was tested for 42 described mutations in multiple genes including renin (REN), beta-tubulin (TUBB2B), biotinidase (BTD), sphingomyelin phosphodiesterase-1 (SMPD1), phenylalanine hydroxylase (PAH) and medium chain Acyl-Coa dehydrogenase (ACADM). Moreover, MODICT scores corresponded to experimentally verified residual enzyme activities in mutated biotinidase, phenylalanine hydroxylase and medium chain Acyl-CoA dehydrogenase. Several commercially available prediction algorithms were tested and

SUBMITTER: Tanyalcin I 

PROVIDER: S-EPMC5070100 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature