Shedding light on the expansion and diversification of the Cdc48 protein family during the rise of the eukaryotic cell.

ABSTRACT:

Background

A defining feature of eukaryotic cells is the presence of various distinct membrane-bound compartments with different metabolic roles. Material exchange between most compartments occurs via a sophisticated vesicle trafficking system. This intricate cellular architecture of eukaryotes appears to have emerged suddenly, about 2 billion years ago, from much less complex ancestors. How the eukaryotic cell acquired its internal complexity is poorly understood, partly because no prokaryotic precursors have been found for many key factors involved in compartmentalization. One exception is the Cdc48 protein family, which consists of several distinct classical ATPases associated with various cellular activities (AAA+) proteins with two consecutive AAA domains.

Results

Here,

SUBMITTER: Kienle N 

PROVIDER: S-EPMC5070193 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature