Validating γ oscillations and delayed auditory responses as translational biomarkers of autism.

ABSTRACT:

Background

Difficulty modeling complex behavioral phenotypes in rodents (e.g., language) has hindered pathophysiological investigation and treatment development for autism spectrum disorders. Recent human neuroimaging studies, however, have identified functional biomarkers that can be more directly related to the abnormal neural dynamics of autism spectrum disorders. This study assessed the translational potential of auditory evoked-response endophenotypes of autism in parallel mouse and human studies of autism.

Methods

Whole-cortex magnetoencephalography was recorded in 17 typically developing and 25 autistic children during auditory pure-tone presentation. Superior temporal gyrus activity was analyzed in time and frequency domains. Auditory evoked potentials were recorded

SUBMITTER: Gandal MJ 

PROVIDER: S-EPMC5070466 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature