Host Genetic Variants in HLA Loci Influence Risk for Hepatitis B Virus Infection in Children.

ABSTRACT:

Background

Hepatitis B virus (HBV) infection is a serious public health problem in China and worldwide. Mother-to-child transmission is one of HBV's main transmission routes in highly endemic regions. Genome-wide association studies (GWAS) identify single nucleotide polymorphisms (SNPs) at HLA loci as associated with HBV infection. However, the mechanisms of HBV perinatal transmission and breakthrough in children have not yet been clearly defined.

Objectives

We aimed to explore the association between SNPs at HLA loci and HBV infection and breakthrough in children.

Methods

A total of 274 HBV-infected children and 353 controls were selected among children aged between 6 months and 12 years in China. Seven SNPs at HLA-DP and HLA-DQ loc

SUBMITTER: Fan J 

PROVIDER: S-EPMC5070562 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature