Androgen Deprivation Therapy and Future Alzheimer's Disease Risk.

ABSTRACT:

Purpose

To test the association of androgen deprivation therapy (ADT) in the treatment of prostate cancer with subsequent Alzheimer's disease risk.

Methods

We used a previously validated and implemented text-processing pipeline to analyze electronic medical record data in a retrospective cohort of patients at Stanford University and Mt. Sinai hospitals. Specifically, we extracted International Classification of Diseases-9th revision diagnosis and Current Procedural Terminology codes, medication lists, and positive-present mentions of drug and disease concepts from all clinical notes. We then tested the effect of ADT on risk of Alzheimer's disease using 1:5 propensity score-matched and traditional multivariable-adjusted Cox proportional hazards models. The duration of ADT use

SUBMITTER: Nead KT 

PROVIDER: S-EPMC5070576 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature