Aberrant Food Choices after Satiation in Human Orexin-Deficient Narcolepsy Type 1.

ABSTRACT:

Study objectives

Besides influencing vigilance, orexin neurotransmission serves a variety of functions, including reward, motivation, and appetite regulation. As obesity is an important symptom in orexin-deficient narcolepsy, we explored the effects of satiety on food-related choices and spontaneous snack intake in patients with narcolepsy type 1 (n = 24) compared with healthy matched controls (n = 19). In additional analyses, we also included patients with idiopathic hypersomnia (n = 14) to assess sleepiness-related influences.

Methods

Participants were first trained on a choice task to earn salty and sweet snacks. Next, one of the snack outcomes was devalued by having participants consume it until satiation (i.e., sensory-specific satiety). We then measured the selective r

SUBMITTER: van Holst RJ 

PROVIDER: S-EPMC5070749 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature