Revisiting Recombination Signal in the Tick-Borne Encephalitis Virus: A Simulation Approach.

ABSTRACT: The hypothesis of wide spread reticulate evolution in Tick-Borne Encephalitis virus (TBEV) has recently gained momentum with several publications describing past recombination events involving various TBEV clades. Despite a large body of work, no consensus has yet emerged on TBEV evolutionary dynamics. Understanding the occurrence and frequency of recombination in TBEV bears significant impact on epidemiology, evolution, and vaccination with live vaccines. In this study, we investigated the possibility of detecting recombination events in TBEV by simulating recombinations at several locations on the virus' phylogenetic tree and for different lengths of recombining fragments. We derived estimations of rates of true and false positive for the detection of past recombination events for seven

SUBMITTER: Bertrand YJ 

PROVIDER: S-EPMC5070875 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature