Genetic structure of the Newfoundland and Labrador population: founder effects modulate variability.

ABSTRACT: The population of the province of Newfoundland and Labrador (NL) has been a resource for genetic studies because of its historical isolation and increased prevalence of several monogenic disorders. Controversy remains regarding the genetic substructure and the extent of genetic homogeneity, which have implications for disease gene mapping. Population substructure has been reported from other isolated populations such as Iceland, Finland and Sardinia. We undertook this study to further our understanding of the genetic architecture of the NL population. We enrolled 494 individuals randomly selected from NL. Genome-wide SNP data were analyzed together with that from 14 other populations including HapMap3, Ireland, Britain and Native American samples from the Human Genome Diversity Project. Us

SUBMITTER: Zhai G 

PROVIDER: S-EPMC5070906 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature