Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk: A Secondary Analysis of the Women's Health Initiative Randomized Clinical Trials.

ABSTRACT:

Importance

More than two-thirds of US women are overweight or obese, placing them at increased risk for postmenopausal breast cancer.

Objective

To investigate in this secondary analysis the associations of overweight and obesity with risk of postmenopausal invasive breast cancer after extended follow-up in the Women's Health Initiative (WHI) clinical trials.

Design, setting, and participants

The WHI clinical trial protocol incorporated measured height and weight, baseline and annual or biennial mammography, and adjudicated breast cancer end points in 67 142 postmenopausal women ages 50 to 79 years at 40 US clinical centers. The women were enrolled from 1993 to 1998 with a median of 13 years of follow-up through 2010; 3388 invasive breast cancers were observed.

Main

SUBMITTER: Neuhouser ML 

PROVIDER: S-EPMC5070941 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature