Acquired resistance to innate immune clearance promotes Klebsiella pneumoniae ST258 pulmonary infection.

ABSTRACT: Adaptive changes in the genome of a locally predominant clinical isolate of the multidrug-resistant Klebsiella pneumoniae ST258 (KP35) were identified and help to explain the selection of this strain as a successful pulmonary pathogen. The acquisition of 4 new ortholog groups, including an arginine transporter, enabled KP35 to outcompete related ST258 strains lacking these genes. KP35 infection elicited a monocytic response, dominated by Ly6C^hi monocytic myeloid-derived suppressor cells that lacked phagocytic capabilities, expressed IL-10, arginase, and antiinflammatory surface markers. In comparison with other K. pneumoniae strains, KP35 induced global changes in the phagocytic response identified with proteomics, including evasion of Ca²⁺ and ca

SUBMITTER: Ahn D 

PROVIDER: S-EPMC5070956 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature