A biomarker-responsive T_2ex MRI contrast agent.

ABSTRACT:

Purpose

This study investigated a fundamentally new type of responsive MRI contrast agent for molecular imaging that alters T₂ exchange (T_2ex ) properties after interacting with a molecular biomarker.

Methods

The contrast agent Tm-DO3A-oAA was treated with nitric oxide (NO) and O₂ . The R₁ and R₂ relaxation rates of the reactant and product were measured with respect to concentration, temperature, and pH. Chemical exchange saturation transfer (CEST) spectra of the reactant and product were acquired using a 7 Tesla (T) MRI scanner and analyzed to estimate the chemical exchange rates and r_2ex relaxivities.

Results

The reaction of Tm-DO3A-oAA with NO and O₂ caused a 6.4-fold increase in the r

SUBMITTER: Daryaei I 

PROVIDER: S-EPMC5071101 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature