ALTERED TOPOGRAPHY OF INTRINSIC FUNCTIONAL CONNECTIVITY IN CHILDHOOD RISK FOR SOCIAL ANXIETY.

ABSTRACT:

Background

Extreme shyness in childhood arising from behavioral inhibition (BI) is among the strongest risk factors for developing social anxiety. Although no imaging studies of intrinsic brain networks in children with BI have been reported, adults with a history of BI exhibit altered functioning of frontolimbic circuits and enhanced processing of salient, personally relevant information. BI in childhood may be marked by increased coupling of salience (insula) and default (ventromedial prefrontal cortex [vmPFC]) network hubs.

Methods

We tested this potential relation in 42 children ages 9-12, oversampled for high BI. Participants provided resting-state functional magnetic resonance imaging. A novel topographical pattern analysis of salience network intrinsic functional conn

SUBMITTER: Taber-Thomas BC 

PROVIDER: S-EPMC5071108 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature